Phuturdex › Diseases › Congenital syphilis
Drugs in development · updated 5 November 2026
Congenital syphilis: drugs in development
What it is
A rare teratologic disease caused by vertical transmission of the spirochete Treponema pallidum from an infected mother to the fetus, characterized by early congenital syphilis during the first two years of life (maculopapular rash progressing to desquamation, hepatosplenomegaly, osteochondritis, snuffles, and iritis), followed by late congenital syphilis with the classic Hutchinson's triad of Hutchinson's teeth, interstitial keratitis, and eighth nerve deafness. Additional signs may include saddle nose, saber shins, seizures, and mental retardation. Congenital syphilis can also result in stillbirth, neonatal death, and nonimmune hydrops.
Source: Orphanet, “Congenital syphilis” (ORPHA:499009), www.orpha.net · licence CC BY 4.0 · Orphadata data of 23 June 2026.
As of 5 November 2026 there are 2 active clinical trials (recruiting or ongoing, phases I–III) on 3 drugs for congenital syphilis. 0 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 5 November 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AmoxicillinAmoxycillin, Moxatag® | II | 1 | NCT06921213 |
| Benzathine penicillin | II | 1 | NCT07189208 |
| LinezolidLinezolid In Sodium Chloride 0.9% In Plastic Container®, Zyvox® | II | 1 | NCT06921213 |
Sorted by most advanced phase and number of active trials.
All 3 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Broader categories
- Infection 874 drugs
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities 951 drugs
- Bacterial Infections 203 drugs
- Gram-negative bacterial infection 41 drugs
- Syphilis 8 drugs
- Treponemal Infections 9 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 5 November 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D013590 “Syphilis, Congenital”. Prevalence: Orphanet.