Phuturdex › Diseases › Post-dural-puncture headache
Drugs in development · updated 30 October 2026
Post-dural-puncture headache: drugs in development
As of 30 October 2026 there are 3 active clinical trials (recruiting or ongoing, phases I–III) on 4 drugs for post-dural-puncture headache. 0 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Neostigmine | I–II | 2 | NCT06729047 |
| GlycopyrroniumGlycopyrrolate, Dartisla Odt® | II | 1 | NCT05116930 |
| KetorolacAcuvail®, Sprix® | I–II | 1 | NCT06729047 |
| LidocaineXylocaine, Bondlido® | Early I | 1 | NCT06824025 |
Sorted by most advanced phase and number of active trials.
All 4 drugs, with the details
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Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D051299 “Post-Dural Puncture Headache”.