Phuturdex › Diseases › Treatment-resistant schizophrenia
Drugs in development · updated 9 November 2026
Treatment-resistant schizophrenia: drugs in development
What it is
A subset of schizophrenia with an inadequate response in target symptoms following treatment with two or more ANTIPSYCHOTICS.
Source: NLM MeSH (U.S. National Library of Medicine), descriptor D000090663, meshb.nlm.nih.gov · public domain · downloaded on 9 November 2026.
As of 9 November 2026 there are 2 active clinical trials (recruiting or ongoing, phases I–III) on 4 drugs for treatment-resistant schizophrenia. One is experimental, that is not yet approved in the United States.
Summary updated every week · data as of 9 November 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Evenamide | III | 1 | NCT07184619 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AmisulprideBarhemsys® | III | 1 | NCT07918222 |
| AripiprazoleAbilify Asimtufii®, Opipza® | III | 1 | NCT07918222 |
| ClozapineVersacloz®, Fazaclo Odt® | III | 1 | NCT07918222 |
Sorted by most advanced phase and number of active trials.
All 4 drugs, with the details
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Open in Phuturdex →Broader categories
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 9 November 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D000090663 “Schizophrenia, Treatment-Resistant”.