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Drugs in development · updated 30 October 2026

APG-157: clinical trials and development status

Development codeNot approved in the USNo EMA authorisationEstimated launch Feb 2033 – Dec 2033 (Phuturdex estimate)

As of 30 October 2026 APG-157 is in 4 active clinical trials (recruiting or ongoing, phases I–III) for 6 diseases. The most advanced phase is III.

4Active trials
IIIMost advanced phase
6Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow APG-157 and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Head and neck neoplasmsIII2NCT07667296
Head and neck squamous cell carcinomaIII2NCT07667296
Mouth NeoplasmsIII2NCT07667296
GlioblastomaI–II1NCT06011109
GliomaI–II1NCT06011109
Oropharyngeal NeoplasmsII1NCT05312710

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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