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Drugs in development · updated 30 October 2026

Defibrotide: clinical trials and development status

Other names and codes: Defitelio

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 18 October 2013

As of 30 October 2026 Defibrotide is in 3 active clinical trials (recruiting or ongoing, phases I–III) for 3 diseases. The most advanced phase is II.

3Active trials
IIMost advanced phase
3Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Defibrotide and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
COVID-19II1NCT04652115
Hepatic veno-occlusive diseaseII1NCT05987124
Sickle-cell diseaseII1NCT02675959

Everything on Defibrotide

In Phuturdex you get every trial with sponsors, countries and dates, development events, FDA and EMA approvals, patents and exclusivities, orphan designations and safety alerts, with PDF and Excel export. Free until 31 March 2027.

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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