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Drugs in development · updated 30 October 2026

Enasidenib: clinical trials and development status

Other names and codes: AG-221, Idhifa

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 Enasidenib is in 20 active clinical trials (recruiting or ongoing, phases I–III) for 12 diseases. The most advanced phase is III.

20Active trials
IIIMost advanced phase
12Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Enasidenib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Acute myeloid leukemiaIII14NCT03839771
Myelodysplastic SyndromesII4NCT05564390
Chronic myelomonocytic leukemiaII2NCT03683433
Acute biphenotypic leukaemiaII1NCT03683433
ChondrosarcomaII1NCT06176989
EsthesioneuroblastomaII1NCT06176989
LeukemiaI–II1NCT02677922
Myeloproliferative disordersII1NCT05564390
NeoplasmI–II1NCT02813135
Refractory anemia with excess of blastsII1NCT03383575
Sinonasal undifferentiated carcinomaII1NCT06176989
T-cell lymphomaII1NCT06756308

Everything on Enasidenib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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