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Drugs in development · updated 30 October 2026

Orelabrutinib: clinical trials and development status

Other names and codes: ICP-022

NLM verified identityNot approved in the USNo EMA authorisationEstimated launch Jun 2028 – Apr 2029 (Phuturdex estimate)

As of 30 October 2026 Orelabrutinib is in 56 active clinical trials (recruiting or ongoing, phases I–III) for 12 diseases. The most advanced phase is III.

56Active trials
IIIMost advanced phase
12Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Orelabrutinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Lymphoma, B-Cell, Marginal ZoneIII17NCT07896590
Mantle cell lymphomaIII9NCT07784101
Follicular lymphomaIII3NCT07719855
Autoimmune thrombocytopenic purpuraIII2NCT07559331
Chronic progressive multiple sclerosisIII2NCT07067463
Hematologic neoplasmII–III2NCT06378138
Diffuse large B-cell lymphomaII4NCT07499271
Interdigitating dendritic cell sarcomaII2NCT07680933
LymphomaII2NCT07441993
Chronic lymphocytic leukemiaII1NCT06958705
Amyotrophic lateral sclerosisI1NCT07875972
Neuroinflammatory diseasesI1NCT07875972

Everything on Orelabrutinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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