Phuturdex › Diseases › Cognitive dysfunction
Drugs in development · updated 30 October 2026
Cognitive dysfunction: drugs in development
As of 30 October 2026 there are 92 active clinical trials (recruiting or ongoing, phases I–III) on 94 drugs for cognitive dysfunction. 47 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 47 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| DonanemabKisunla® | III | 3 | NCT05508789 |
| MetforminRiomet Er®, Glumetza® | II–III | 3 | NCT04098666 |
| LecanemabLeqembi Iqlik®, Leqembi® | III | 2 | NCT03887455 |
| AmlodipineSdamlo®, Norliqva® | III | 1 | NCT05155137 |
| CaffeineCafcit®, Gencebok® | III | 1 | NCT04570085 |
| GonadorelinGnRH, Luteinizing Hormone Releasing Hormone | II–III | 1 | NCT04390646 |
| MidazolamMidazolam Hydrochloride (Autoinjector)®, Midazolam In 0.8% Sodium Chloride® | III | 1 | NCT07113483 |
| RemimazolamByfavo® | III | 1 | NCT07113483 |
| RosuvastatinEzallor Sprinkle®, Crestor® | III | 1 | NCT05155137 |
| Vizamyl18F-Flutemetamol, flutemetamol F 18 | II | 3 | NCT07873463 |
| 18F-AV-1451[18F] Flortaucipir, Flortaucipir F18 | II | 2 | NCT06723015 |
| DaridorexantQuviviq® | II | 2 | NCT07217912 |
| DasatinibPhyrago®, Sprycel® | I–II | 2 | NCT04785300 |
| MemantineNamenda, Memantine Mylan® | II | 2 | NCT06727773 |
| AtorvastatinLipitor, Atorvaliq® | II | 1 | NCT04765137 |
Sorted by most advanced phase and number of active trials. Showing 15 of 47 drugs.
All 94 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
Broader categories
- Mental disorder 24 drugs
- Cognition Disorders 6 drugs
- Neurocognitive Disorders 10 drugs
- Nervous System Diseases 39 drugs
- Central nervous system disease 38 drugs
- Brain Diseases 23 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D060825 “Cognitive Dysfunction”.