Phuturdex › Diseases › Intellectual disability
Drugs in development · updated 30 October 2026
Intellectual disability: drugs in development
As of 30 October 2026 there are 8 active clinical trials (recruiting or ongoing, phases I–III) on 7 drugs for intellectual disability. 4 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| TSHA-102 | III | 2 | NCT07480564 |
| GNR-055 | II–III | 1 | NCT05208281 |
| NGN-401 | III | 1 | NCT05898620 |
| CTH120 | II | 1 | NCT07654114 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Oxytocin nasal sprayOxytocin 10 Usp Units In Dextrose 5%®, Oxytocin 5 Usp Units In Dextrose 5%® | II | 1 | NCT05864508 |
| MemantineNamenda, Memantine Mylan® | I | 1 | NCT07531940 |
| MethylphenidateConcerta, Relexxii® | I | 1 | NCT05301361 |
Sorted by most advanced phase and number of active trials.
All 7 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Down syndrome 36 drugs
- Mucopolysaccharidosis II 15 drugs
- Rett syndrome 8 drugs
- Fragile X syndrome 10 drugs
- Prader–Willi syndrome 5 drugs
- Alzheimer's disease 157 drugs
- Pyruvate Dehydrogenase Complex Deficiency Disease 3 drugs
- Burkitt lymphoma 113 drugs
- Mucopolysaccharidosis I 7 drugs
- Leukodystrophy, Globoid Cell 8 drugs
- Metachromatic leukodystrophy 7 drugs
- Adrenoleukodystrophy 6 drugs
Broader categories
- Mental disorder 24 drugs
- Genetic disease 33 drugs
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities 4 drugs
- Neurobehavioral manifestation 8 drugs
- Nervous system heredodegenerative disease 3 drugs
- Nervous System Diseases 39 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D008607 “Intellectual Disability”.