Phuturdex › Diseases › Periodontal disease
Drugs in development · updated 30 October 2026
Periodontal disease: drugs in development
As of 30 October 2026 there are 3 active clinical trials (recruiting or ongoing, phases I–III) on 3 drugs for periodontal disease. 2 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| XylitolD-xylitol | II–III | 1 | NCT07424846 |
| Hyaluronic Acid | I–II | 1 | NCT07737678 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Chlorhexidine 2% | I–II | 1 | NCT07791238 |
Sorted by most advanced phase and number of active trials.
All 3 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Periodontitis 9 drugs
- Gingivitis 5 drugs
- Periapical periodontitis 5 drugs
- Postoperative pain 50 drugs
- Type 2 diabetes 171 drugs
- Dental pulp necrosis 3 drugs
- Dental pulp disease 5 drugs
- Dental plaque 3 drugs
- Hemorrhage 25 drugs
Broader categories
- Stomatognathic disease 4 drugs
- Female urogenital diseases and pregnancy complications 3 drugs
- Urogenital Diseases 16 drugs
- Infection 71 drugs
- Obstetric labor complication 4 drugs
- Complications of pregnancy 3 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D010510 “Periodontal Diseases”.