Phuturdex › Diseases › Pulpitis
Drugs in development · updated 9 November 2026
Pulpitis: drugs in development
What it is
Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels, the nerves, and connective tissue inside a tooth and provides the tooth's blood and nutrients. Pulpitis is mainly caused by bacterial infection which itself is a secondary development of caries (tooth decay). It manifests itself in the form of a toothache.
Description not checked by Phuturdex: excerpt from the introduction of the article “Pulpitis” on English Wikipedia, en.wikipedia.org · version of 2 August 2026 · licence CC BY-SA 4.0.
As of 9 November 2026 there are 1 active clinical trials (recruiting or ongoing, phases I–III) on 4 drugs for pulpitis. 0 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 9 November 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ArticaineCyklx® | III | 1 | NCT07919938 |
| DexamethasoneDexametasone, dexamethsone | III | 1 | NCT07919938 |
| DiclofenacVoltaren Topical Gel, Zueino® | III | 1 | NCT07919938 |
| EpinephrineAdrenaline, Epinephrine Bitartrate In 0.9% Sodium Chloride® | III | 1 | NCT07919938 |
Sorted by most advanced phase and number of active trials.
All 4 drugs, with the details
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Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 9 November 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: NLM MeSH; NLM MeSH term: D011671 “Pulpitis”.