Phuturdex › Diseases › Retinal degeneration
Drugs in development · updated 30 October 2026
Retinal degeneration: drugs in development
As of 30 October 2026 there are 15 active clinical trials (recruiting or ongoing, phases I–III) on 15 drugs for retinal degeneration. 9 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AGTC-501 | II | 1 | NCT06275620 |
| GT005 | II | 1 | NCT05481827 |
| OpCT-001 | I–II | 1 | NCT06789445 |
| SPVN06 | I–II | 1 | NCT05748873 |
| SPVN20 | I–II | 1 | NCT07807111 |
| VG801 | I–II | 1 | NCT07002398 |
| VP-001 | I–II | 1 | NCT06852963 |
| AXV-101 | Early I | 1 | NCT07269665 |
| IVB102 | Early I | 1 | NCT06289452 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AfliberceptEYLEA Injection, Ziv-Aflibercept | III | 1 | NCT05407636 |
| RanibizumabLucentis, Ranluspec® | II–III | 1 | NCT04704921 |
| AdalimumabHadlima, Simlandi® | I–II | 1 | NCT07348588 |
| DapagliflozinForxiga, Dapagliflozin Propanediol | II | 1 | NCT07174687 |
| MetforminRiomet Er®, Glumetza® | I–II | 1 | NCT04545736 |
| MinocyclineMinocyclin, Emrosi® | I–II | 1 | NCT05474729 |
Sorted by most advanced phase and number of active trials.
All 15 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Macular degeneration 40 drugs
- Retinitis pigmentosa 25 drugs
- Geographic atrophy 26 drugs
- Macular retinal edema 15 drugs
- Stargardt disease 14 drugs
- Wet Macular Degeneration 7 drugs
- Diabetic retinopathy 17 drugs
- Eye disease 19 drugs
- Choroidal neovascularization 5 drugs
- Usher Syndromes 5 drugs
- Retinal disease 18 drugs
- Retinal Dystrophies 8 drugs
Broader categories
- Hereditary eye disease 4 drugs
- Eye disease 19 drugs
- Genetic disease 33 drugs
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities 4 drugs
- Retinal disease 18 drugs
- Macular degeneration 40 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D012162 “Retinal Degeneration”.