Phuturdex › Diseases › Sleep-wake disorder
Drugs in development · updated 30 October 2026
Sleep-wake disorder: drugs in development
As of 30 October 2026 there are 14 active clinical trials (recruiting or ongoing, phases I–III) on 11 drugs for sleep-wake disorder. 6 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ALKS 2680 | II–III | 5 | NCT06767683 |
| Berobenatide | III | 2 | NCT07881757 |
| Cleminorexton | II–III | 1 | NCT07598708 |
| Tegileridine | III | 1 | NCT07844512 |
| AFA-281 | II | 1 | NCT06710431 |
| MelatoninSlenyto®, Circadin® | II | 1 | NCT01628029 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| SufentanilDsuvia®, Sufenta Preservative Free® | III | 1 | NCT07844512 |
| TasimelteonHetlioz Lq®, Hetlioz® | III | 1 | NCT06701396 |
| MethylphenidateConcerta, Relexxii® | II | 1 | NCT01628029 |
| MirtazapineRemeron Soltab®, Remeron® | II | 1 | NCT07430046 |
| TrazodoneRaldesy®, Oleptro® | Early I | 1 | NCT06281756 |
Sorted by most advanced phase and number of active trials.
All 11 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Obstructive sleep apnea 32 drugs
- Sleep Initiation and Maintenance Disorders 20 drugs
- Obesity 233 drugs
- Sleep apnea 10 drugs
- REM sleep behavior disorder 6 drugs
- Idiopathic hypersomnia 7 drugs
- Disorders of Excessive Somnolence 10 drugs
- Narcolepsy 10 drugs
- Overweight 139 drugs
- Restless legs syndrome 5 drugs
- Circadian rhythm sleep disorder 4 drugs
- Parasomnia 4 drugs
Broader categories
- Nervous System Diseases 39 drugs
- Mental disorder 24 drugs
- Neurologic Manifestations 15 drugs
- Respiratory disease 57 drugs
- Nutritional and metabolic diseases 5 drugs
- Overnutrition 5 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D012893 “Sleep Wake Disorders”.