Phuturdex › Diseases › Disorders of Excessive Somnolence
Drugs in development · updated 30 October 2026
Disorders of Excessive Somnolence: drugs in development
As of 30 October 2026 there are 15 active clinical trials (recruiting or ongoing, phases I–III) on 10 drugs for disorders of Excessive Somnolence. 8 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ALKS 2680 | II–III | 5 | NCT06767683 |
| Berobenatide | III | 1 | NCT07881757 |
| Cleminorexton | II–III | 1 | NCT07598708 |
| HBS-301 | III | 1 | NCT07500090 |
| Samelisant | III | 1 | NCT07540364 |
| ALKS 7290 | II | 1 | NCT07901179 |
| ORX750 | II | 1 | NCT07096674 |
| ORX142 | I | 1 | NCT07082829 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| SolriamfetolSunosi® | III | 2 | NCT07484217 |
| PitolisantWakix®, Ozawade® | III | 1 | NCT06366464 |
Sorted by most advanced phase and number of active trials.
All 10 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Idiopathic hypersomnia 7 drugs
- Narcolepsy 10 drugs
- Sleep Initiation and Maintenance Disorders 20 drugs
- REM sleep behavior disorder 6 drugs
- Circadian rhythm sleep disorder 4 drugs
- Combat disorder 4 drugs
- Anxiety disorder 32 drugs
- Depression 73 drugs
- Well-being 10 drugs
- Alzheimer's disease 157 drugs
- Post-traumatic stress disorder 39 drugs
- Pain 75 drugs
Broader categories
- Nervous System Diseases 39 drugs
- Mental disorder 24 drugs
- Sleep-wake disorder 11 drugs
- Neurologic Manifestations 15 drugs
- Depressive disorder 12 drugs
- Mood disorder 8 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: NLM MeSH; NLM MeSH term: D006970 “Disorders of Excessive Somnolence”.