Drugs in development · updated 30 October 2026
Pain: drugs in development
As of 30 October 2026 there are 95 active clinical trials (recruiting or ongoing, phases I–III) on 75 drugs for pain. 20 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Cebranopadol | III | 2 | NCT07845071 |
| Neridronate | III | 2 | NCT07210515 |
| DIPYRONEMetamizole | III | 1 | NCT06237231 |
| DIT112 | III | 1 | NCT06237231 |
| Glucose20% D-glucose | II–III | 1 | NCT07493785 |
| Ozone | II–III | 1 | NCT04299893 |
| Hydroxynorketamine | I–II | 2 | NCT05864053 |
| Pregnenolone | II | 2 | NCT06188923 |
| Allopregnanolone | II | 1 | NCT04003285 |
| Epsom salt | II | 1 | NCT06393608 |
| Halneuron | II | 1 | NCT06848348 |
| KBP-336 | II | 1 | NCT06833749 |
| Lysergic Acid Diethylamide Tartrate | II | 1 | NCT05883540 |
| Proglumide | I–II | 1 | NCT05551858 |
| VMD-3866 | II | 1 | NCT07072468 |
| PsilocybinPsilocybine | I | 4 | NCT05224336 |
| BRC-002 | I | 1 | NCT06393101 |
| IG001119 | I | 1 | NCT07618247 |
| SBS-147 | I | 1 | NCT07335913 |
| MDMA3,4-Methylenedioxymethamphetamine, Midomafetamine HCl | Early I | 1 | NCT06066853 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| KetamineKetalar® | II–III | 11 | NCT07276542 |
| DexamethasoneDexametasone, Dextenza | II–III | 6 | NCT07853664 |
| DexmedetomidineIgalmi®, Precedex® | II–III | 4 | NCT07493785 |
| MorphineArymo Er®, Morphabond Er® | II–III | 4 | NCT04011163 |
| OxycodoneOxyContin, Roxybond® | III | 4 | NCT04659317 |
| FentanylFentanyl Citrate Buccal Tablet, Subsys® | III | 3 | NCT06464146 |
| KetorolacAcuvail®, Sprix® | III | 3 | NCT07816302 |
| BupivacaineExparel, Bupivacain | II–III | 2 | NCT06077422 |
| DiclofenacVoltaren Topical Gel, Zueino® | II–III | 2 | NCT07853664 |
| EpinephrineAdrenaline, Adrenalin® | III | 2 | NCT05964868 |
| Sodium BicarbonateSodium Bicarbonate In Plastic Container® | II–III | 2 | NCT06999993 |
| SuzetrigineJournavx® | III | 2 | NCT07864896 |
| Tranexamic AcidTransexamic acid, Lysteda® | III | 2 | NCT07880743 |
| AcetaminophenParacetamol, APAP | III | 1 | NCT03823534 |
| ArticaineCyklx® | III | 1 | NCT05839548 |
Sorted by most advanced phase and number of active trials. Showing 15 of 55 drugs.
All 75 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Postoperative pain 50 drugs
- Chronic pain 40 drugs
- Neuralgia 21 drugs
- Headache 12 drugs
- Acute pain 20 drugs
- Lower back pain 12 drugs
- Migraine 28 drugs
- Back pain 8 drugs
- Cancer pain 11 drugs
- Breast neoplasm 593 drugs
- Arthralgia 5 drugs
- Endometriosis 16 drugs
Broader categories
- Neurologic Manifestations 15 drugs
- Nervous System Diseases 39 drugs
- Mental disorder 24 drugs
- Postoperative complications 4 drugs
- Musculoskeletal disorder 22 drugs
- Neuromuscular disease 14 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D010146 “Pain”.