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Drugs in development · updated 30 October 2026

Hydroxynorketamine: clinical trials and development status

FDA substance registryNot approved in the USNo EMA authorisation

As of 30 October 2026 Hydroxynorketamine is in 4 active clinical trials (recruiting or ongoing, phases I–III) for 12 diseases. The most advanced phase is II.

4Active trials
IIMost advanced phase
12Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Hydroxynorketamine and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
PainII2NCT07504601
Behavioral symptomsII1NCT06511908
Chronic painI–II1NCT05864053
DepressionII1NCT06511908
Depressive disorderII1NCT06511908
Depressive Disorder, Treatment-ResistantII1NCT06511908
Major depressive disorderII1NCT06511908
Mental disorderII1NCT06511908
Mood disorderII1NCT06511908
NeuralgiaI–II1NCT05864053
Obsessive-compulsive disorderI–II1NCT06575075
SuicideII1NCT06511908

Everything on Hydroxynorketamine

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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