Phuturdex › Diseases › Depressive Disorder, Treatment-Resistant
Drugs in development · updated 30 October 2026
Depressive Disorder, Treatment-Resistant: drugs in development
As of 30 October 2026 there are 41 active clinical trials (recruiting or ongoing, phases I–III) on 21 drugs for depressive Disorder, Treatment-Resistant. 8 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| PsilocybinPsilocybine | III | 14 | NCT05711940 |
| NRX-101 | II–III | 1 | NCT07227103 |
| ACP-211 | II | 1 | NCT07284667 |
| ALTO-207 | II | 1 | NCT07553637 |
| BPL-003 | II | 1 | NCT05660642 |
| Hydroxynorketamine | II | 1 | NCT06511908 |
| OSU6162 | II | 1 | NCT05641623 |
| Quercetin | II | 1 | NCT05838560 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| KetamineKetalar® | II–III | 11 | NCT07801703 |
| MidazolamMidazolam Hydrochloride (Autoinjector)®, Midazolam In 0.8% Sodium Chloride® | III | 4 | NCT05625555 |
| EsketamineSpravato | III | 3 | NCT07716098 |
| BrexpiprazoleRexulti®, Rxulti® | III | 1 | NCT04569448 |
| DHEAdehydroepiandrosterone, Prasterone | III | 1 | NCT07843927 |
| LumateperoneCaplyta® | III | 1 | NCT07623135 |
| QuetiapineSeroquel Xr® | III | 1 | NCT07760168 |
| AripiprazoleAbilify Asimtufii®, Opipza® | II | 1 | NCT07810738 |
| BupropionForfivo Xl®, Aplenzin® | II | 1 | NCT07810738 |
| DasatinibPhyrago®, Sprycel® | II | 1 | NCT05838560 |
| RisperidoneRisvan®, Uzedy® | II | 1 | NCT06512220 |
| TrazodoneRaldesy®, Oleptro® | II | 1 | NCT07210112 |
| Nitrous OxideNitrous Oxide, Usp® | I | 1 | NCT02994433 |
Sorted by most advanced phase and number of active trials.
All 21 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Broader categories
- Depressive disorder 12 drugs
- Mood disorder 8 drugs
- Mental disorder 24 drugs
- Self-Injurious Behavior 5 drugs
- Pain 75 drugs
- Neurologic Manifestations 15 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: NLM MeSH; NLM MeSH term: D061218 “Depressive Disorder, Treatment-Resistant”.