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Drugs in development · updated 30 October 2026

Pregnenolone: clinical trials and development status

NLM verified identityNot approved in the USNo EMA authorisation

As of 30 October 2026 Pregnenolone is in 7 active clinical trials (recruiting or ongoing, phases I–III) for 7 diseases. The most advanced phase is II.

7Active trials
IIMost advanced phase
7Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Pregnenolone and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
DepressionII3NCT06188923
Major depressive disorderII3NCT07734701
AlcoholismII2NCT07734701
Anxiety disorderII2NCT06188923
PainII2NCT06188923
Marijuana AbuseII1NCT07216690
Substance-related disorderII1NCT07734701

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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