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Drugs in development · updated 30 October 2026

Entacapone: clinical trials and development status

Other names and codes: Comtan, Comtess

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 16 September 1998

As of 30 October 2026 Entacapone is in 4 active clinical trials (recruiting or ongoing, phases I–III) for 8 diseases. The most advanced phase is III.

4Active trials
IIIMost advanced phase
8Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Entacapone and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Parkinson's diseaseIII2NCT07151378
Impulse control disorderIII1NCT07151378
GlioblastomaI–II1NCT07831187
Postural orthostatic tachycardia syndromeI–II1NCT00262470
Sinus tachycardiaI–II1NCT00262470
TachycardiaI–II1NCT00262470
Multiple system atrophyI1NCT04246437
Pure autonomic failureI1NCT04246437

Everything on Entacapone

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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