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Drugs in development · updated 30 October 2026

Parkinson's disease: drugs in development

As of 30 October 2026 there are 104 active clinical trials (recruiting or ongoing, phases I–III) on 104 drugs for Parkinson's disease. 74 are experimental, that is not yet approved in the United States.

104Active trials
74Experimental drugs
11Experimental, in phase III

Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.

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Experimental drugs

Not yet approved by the US FDA for any indication.

DrugMost advanced phaseActive trialsReference trial
PrasinezumabRO7046015III4NCT07174310
Ambroxol HydrochlorideIII1NCT05778617
BemdaneprocelIII1NCT06944522
BHV-8000II–III1NCT06976268
BuntanetapII–III1NCT07284784
CVN424III1NCT06553027
ONO-2808III1NCT07825402
PosiphenII–III1NCT07284784
TJ0113III1NCT07741045
VG081821ACII–III1NCT07725562
VinpocetineII–III1NCT07229664
AB-1005II2NCT07215403
GT-02287II2NCT07280299
PsilocybinPsilocybineII2NCT07610369
TributyrinGlycerol TributyrateI–II2NCT07863180
18F-MFBGII1NCT07176286
18F-OP-801I–II1NCT05395624
[18F] AV-133II1NCT07830654
[18F]PI-2620II1NCT07020026
AP-472II1NCT07432958
BIA 28-6156II1NCT05819359
BIIB122II1NCT06602193
DapansutrileII1NCT07157735
DPA-714-PETI–II1NCT03457493
EtoricoxibII1NCT07370532
HBI-002II1NCT07005180
IRL757I–II1NCT07461220
LY3884961I–II1NCT04127578
MelatoninSlenyto®, Circadin®II1NCT07375693
MT101-5II1NCT06175767
ND0612II1NCT02726386
NEU-411II1NCT06680830
NYX-458II1NCT04148391
PlacaboII1NCT07903038
RadotinibII1NCT04691661
ResveratrolTrans-ResveratrolII1NCT07592767
RO7568282I–II1NCT07781644
SilymarinII1NCT07001150
TalineurenII1NCT06431971
TB006II1NCT06773962

Sorted by most advanced phase and number of active trials. Showing 40 of 74 drugs.

Approved drugs in new trials

Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.

DrugMost advanced phaseActive trialsReference trial
CarbidopaLodosyn®II–III4NCT06785298
LevodopaL-DOPA, Inbrija®II–III3NCT06785298
18F-DOPA18F-FDOPA, Fluorodopa F 18III2NCT04706910
EntacaponeComtan®, Entacapone Orion®III2NCT07151378
MetforminRiomet Er®, Glumetza®II–III2NCT07229651
TerazosinTerazosine, Tezruly®III2NCT07207057
Apomorphine infusionOnapgo®, Kynmobi®III1NCT02339064
AtomoxetineAtoncy®, Strattera®III1NCT07316296
FexofenadineChildren'S Allegra Hives®, Children'S Allegra Allergy®II–III1NCT06785298
FurosemideLasix Onyu®, Furoscix®III1NCT04706910
SafinamideXadago®III1NCT07761936
TelmisartanMicardis®, Pritor®III1NCT07207057
KetamineKetalar®II2NCT06231563
AmantadineGocovri, Osmolex Er®II1NCT06817200
CannabidiolEpidiolex, Epidyolex®II1NCT06629389

Sorted by most advanced phase and number of active trials. Showing 15 of 30 drugs.

All 104 drugs, with the details

In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.

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Broader categories

Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D010300 “Parkinson Disease”.

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