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Drugs in development · updated 30 October 2026

Nicotinamide: clinical trials and development status

FDA substance registryNot approved in the USNo EMA authorisationEstimated launch Dec 2027 – Oct 2028 (Phuturdex estimate)

As of 30 October 2026 Nicotinamide is in 13 active clinical trials (recruiting or ongoing, phases I–III) for 18 diseases. The most advanced phase is III.

13Active trials
IIIMost advanced phase
18Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Nicotinamide and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Open-angle glaucomaIII2NCT05405868
Acute kidney injuryIII1NCT04589546
Basal-cell carcinoma of the skinIII1NCT05955924
Septic shockIII1NCT04589546
Squamous cell carcinomaIII1NCT05955924
Chronic lymphocytic leukemiaII1NCT04844528
Fatty liver diseaseII1NCT06599918
Liver cirrhosisII1NCT06599918
Non-alcoholic Fatty Liver DiseaseII1NCT06599918
ObesityII1NCT06599918
OverweightII1NCT06599918
Rheumatoid arthritisII1NCT06640309
Addictive behaviorI1NCT07585006
Leber hereditary optic neuropathyI1NCT07258667
Mitochondrial diseaseI1NCT07258667
Optic nerve diseaseI1NCT07258667
Sickle-cell diseaseI1NCT04055818
Skin neoplasmEarly I1NCT05702398

Everything on Nicotinamide

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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