Phuturdex › Diseases › Rheumatoid arthritis
Drugs in development · updated 30 October 2026
Rheumatoid arthritis: drugs in development
As of 30 October 2026 there are 107 active clinical trials (recruiting or ongoing, phases I–III) on 130 drugs for rheumatoid arthritis. 79 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 79 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| MethotrexateJylamvo®, Reditrex® | II–III | 9 | NCT07627893 |
| AdalimumabHadlima, Simlandi® | III | 5 | NCT03414502 |
| AbataceptOrencia® | III | 4 | NCT03414502 |
| RituximabRuxience, Rituxan | III | 4 | NCT03414502 |
| UpadacitinibRinvoq Lq®, Rinvoq® | III | 3 | NCT02629159 |
| AzathioprineImuran, Jayempi® | III | 2 | NCT03414502 |
| BaricitinibOlumiant® | III | 2 | NCT03414502 |
| Certolizumab | III | 2 | NCT03414502 |
| EtanerceptEticovo®, Erelzi® | III | 2 | NCT03414502 |
| GolimumabImmgolis®, Immgolis Intri® | III | 2 | NCT03414502 |
| HydroxychloroquineSovuna®, Plaquenil® | III | 2 | NCT03414502 |
| InfliximabZymfentra®, Avsola® | III | 2 | NCT03414502 |
| LeflunomideArava®, Leflunomide Zentiva (previously Leflunomide Winthrop)® | III | 2 | NCT03414502 |
| SarilumabSAR153191 SC, Kevzara | III | 2 | NCT03414502 |
| SulfasalazineAzulfidine En-Tabs®, Azulfidine® | III | 2 | NCT03414502 |
Sorted by most advanced phase and number of active trials. Showing 15 of 51 drugs.
All 130 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Sjogren's Syndrome 29 drugs
- Systemic lupus erythematosus 178 drugs
- Systemic scleroderma 77 drugs
- Myositis 42 drugs
- Autoimmune disease 94 drugs
- Anti-neutrophil cytoplasmic antibody-associated vasculitis 35 drugs
- Xerostomia 4 drugs
- Inflammation 85 drugs
- Arthritis, Juvenile 39 drugs
- Dry eye syndrome 18 drugs
- Psoriasis 46 drugs
- Psoriatic arthritis 48 drugs
Broader categories
- Skin and connective tissue diseases 3 drugs
- Immune System Diseases 54 drugs
- Joint Diseases 6 drugs
- Connective tissue disease 21 drugs
- Arthritis 13 drugs
- Rheumatic Diseases 30 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D001172 “Arthritis, Rheumatoid”.