Phuturdex › Diseases › Autoimmune disease
Drugs in development · updated 30 October 2026
Autoimmune disease: drugs in development
As of 30 October 2026 there are 97 active clinical trials (recruiting or ongoing, phases I–III) on 94 drugs for autoimmune disease. 56 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 56 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| CyclophosphamideCyclophosphamid, Cytoxan | II–III | 12 | NCT06154252 |
| FludarabineFludara, FLUDARABIN | II–III | 12 | NCT06154252 |
| BelimumabBenlysta® | III | 2 | NCT06572384 |
| DeucravacitinibBMS-986165, Sotyktu® | III | 2 | NCT05617677 |
| AbataceptOrencia® | III | 1 | NCT04474847 |
| MavorixaforXolremdi® | III | 1 | NCT06056297 |
| PrednisonePredinisone, Cortancyl | II | 3 | NCT03663933 |
| TacrolimusEnvarsus XR, Prograf® | II | 3 | NCT04339777 |
| BusulfanBusulphan, Busulfex® | II | 2 | NCT04339777 |
| CyclosporineCyclosporine A, Cyclosporin Capsules | II | 2 | NCT00977977 |
| Mycophenolate MofetilMycophenolate, Cellcept | II | 2 | NCT04339777 |
| AlemtuzumabCampath, Lemtrada® | II | 1 | NCT04339777 |
| Anti-Thymocyte Globulin | II | 1 | NCT00716066 |
| AtaciceptTrutakna® | II | 1 | NCT06983028 |
| BortezomibVelcade, Bortezomib Hospira® | II | 1 | NCT03993262 |
Sorted by most advanced phase and number of active trials. Showing 15 of 38 drugs.
All 94 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Systemic lupus erythematosus 178 drugs
- Type-1 diabetes 80 drugs
- Rheumatoid arthritis 130 drugs
- Multiple sclerosis 93 drugs
- Autoimmune thrombocytopenic purpura 53 drugs
- IgA glomerulonephritis 48 drugs
- Myasthenia gravis 49 drugs
- Lupus nephritis 64 drugs
- Chronic progressive multiple sclerosis 39 drugs
- Graves' ophthalmopathy 19 drugs
- Anti-neutrophil cytoplasmic antibody-associated vasculitis 35 drugs
- Relapsing-remitting multiple sclerosis 26 drugs
Broader categories
- Immune System Diseases 54 drugs
- Skin and connective tissue diseases 3 drugs
- Connective tissue disease 21 drugs
- Nervous System Diseases 39 drugs
- Skin disease 34 drugs
- Musculoskeletal disorder 22 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D001327 “Autoimmune Diseases”.