Phuturdex › Diseases › Type-1 diabetes
Drugs in development · updated 30 October 2026
Type-1 diabetes: drugs in development
As of 30 October 2026 there are 101 active clinical trials (recruiting or ongoing, phases I–III) on 80 drugs for Type-1 diabetes. 38 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Cadisegliatin | III | 2 | NCT06334133 |
| SAB-142 | III | 2 | NCT07670650 |
| VX-017 | III | 1 | NCT04786262 |
| VX-880 | III | 1 | NCT04786262 |
| Gastrin 17 | I–II | 2 | NCT03746769 |
| VolagidemabREMD-477 | I–II | 2 | NCT05696366 |
| VV-14300 | I–II | 2 | NCT07831798 |
| AMX0035 | II | 1 | NCT07699380 |
| Brivekimig | II | 1 | NCT06812988 |
| CD25 | II | 1 | NCT06688331 |
| CIR-0602K | II | 1 | NCT07186660 |
| CNP-103 | I–II | 1 | NCT06783309 |
| Diamyd | II | 1 | NCT05683990 |
| FrexalimabSAR441344 IV | II | 1 | NCT06111586 |
| ILT101 | II | 1 | NCT05153070 |
| IvarmacitinibSHR0302 | II | 1 | NCT07845955 |
| MTX228 | II | 1 | NCT06474598 |
| OPT101 | II | 1 | NCT06964087 |
| PAL-119 | I–II | 1 | NCT07901595 |
| Rezpegaldesleukin | II | 1 | NCT07142252 |
| SC0062 | II | 1 | NCT06072326 |
| VV-14299 | I–II | 1 | NCT07829302 |
| VX-264 | I–II | 1 | NCT05791201 |
| 10% Fructose Injection | I | 1 | NCT03241706 |
| Degludec | I | 1 | NCT06945406 |
| GNTI-122 | I | 1 | NCT06919354 |
| IMC-S118AI | I | 1 | NCT07493122 |
| Lispro SC | I | 1 | NCT06945406 |
| MTX-101 | I | 1 | NCT06324604 |
| NNC0194-0499 | I | 1 | NCT07087795 |
| NNC0497-0040 | I | 1 | NCT07578584 |
| RGB-5088 | I | 1 | NCT06731218 |
| Somatostatin | I | 1 | NCT03241706 |
| TIX100 | I | 1 | NCT07675590 |
| C-peptide | Early I | 1 | NCT06470295 |
| CRG002 | Early I | 1 | NCT07503028 |
| Dichloroacetate | Early I | 1 | NCT05317455 |
| ResveratrolTrans-Resveratrol | Early I | 1 | NCT04449198 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| SemaglutideWegovy, Rybelsus | II–III | 12 | NCT07891156 |
| SotagliflozinInpefa®, Zynquista® | III | 8 | NCT06217302 |
| TirzepatideZepbound, Mounjaro | II–III | 7 | NCT07284511 |
| VerapamilVerelan Pm®, Covera-Hs® | II–III | 5 | NCT07880769 |
| DapagliflozinForxiga, Dapagliflozin Propanediol | II–III | 4 | NCT03899402 |
| TeplizumabTzield®, Teizeild® | III | 4 | NCT07088068 |
| MetforminRiomet Er®, Glumetza® | III | 3 | NCT04583462 |
| BaricitinibOlumiant® | III | 2 | NCT07222137 |
| FenofibrateFenoglide®, Antara (Micronized)® | III | 2 | NCT01320345 |
| FinerenoneBAY94-8862, Kerendia | III | 2 | NCT06082063 |
| AspirinVazalore®, Durlaza® | III | 1 | NCT06082063 |
| EmpagliflozinJardiance | III | 1 | NCT06894784 |
| Insulin aspartFiasp Penfill®, Fiasp® | III | 1 | NCT07076199 |
| Insulin glargineBasaglar®, Semglee® | III | 1 | NCT07076199 |
| Insulin icodecAwiqli Flextouch®, Awiqli® | III | 1 | NCT07076199 |
Sorted by most advanced phase and number of active trials. Showing 15 of 42 drugs.
All 80 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Broader categories
- Nutritional and metabolic diseases 5 drugs
- Endocrine system disease 19 drugs
- Immune System Diseases 54 drugs
- Glucose metabolism disease 12 drugs
- Metabolic disease 30 drugs
- Autoimmune disease 94 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D003922 “Diabetes Mellitus, Type 1”.