Phuturdex › Diseases › Glucose metabolism disease
Drugs in development · updated 30 October 2026
Glucose metabolism disease: drugs in development
As of 30 October 2026 there are 13 active clinical trials (recruiting or ongoing, phases I–III) on 12 drugs for glucose metabolism disease. 5 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| PF-08653944 | III | 2 | NCT07595549 |
| Retatrutide | III | 2 | NCT06260722 |
| ErsodetugRZ358 | III | 1 | NCT06208215 |
| AMX0035 | II | 1 | NCT07699380 |
| MRNA-3745 | I–II | 1 | NCT05095727 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| OrforglipronFoundayo® | III | 1 | NCT07613307 |
| SemaglutideWegovy, Rybelsus | III | 1 | NCT06260722 |
| TirzepatideZepbound, Mounjaro | II | 2 | NCT06820281 |
| AnakinraKINERET | II | 1 | NCT07580079 |
| DiazoxideProglycem®, Hyperstat® | II | 1 | NCT03540758 |
| NiacinNicotinic acid, Niaspan Titration Starter Pack® | II | 1 | NCT03540758 |
| ColesevelamWelchol®, Cholestagel® | Early I | 1 | NCT06925997 |
Sorted by most advanced phase and number of active trials.
All 12 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Type 2 diabetes 171 drugs
- Type-1 diabetes 80 drugs
- Diabetes 91 drugs
- Obesity 233 drugs
- Overweight 139 drugs
- Insulin resistance 41 drugs
- Hypoglycemia 20 drugs
- Prediabetes 18 drugs
- Cardiovascular disease 71 drugs
- Metabolic syndrome 12 drugs
- Gestational diabetes 9 drugs
- Diabetic Nephropathies 18 drugs
Broader categories
- Nutritional and metabolic diseases 5 drugs
- Metabolic disease 30 drugs
- Diabetes 91 drugs
- Renal Insufficiency 51 drugs
- Urologic Diseases 16 drugs
- Female urogenital disease 11 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D044882 “Glucose Metabolism Disorders”.