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Drugs in development · updated 30 October 2026

Samotolisib: clinical trials and development status

Other names and codes: LY3023414

NLM verified identityNot approved in the USNo EMA authorisation

As of 30 October 2026 Samotolisib is in 3 active clinical trials (recruiting or ongoing, phases I–III) for 19 diseases. The most advanced phase is II.

3Active trials
IIMost advanced phase
19Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Samotolisib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Central nervous system neoplasmII1NCT03155620
Endometrial neoplasmII1NCT03675893
EpendymomaII1NCT03155620
Ewing sarcomaII1NCT03155620
GliomaII1NCT03155620
HepatoblastomaII1NCT03155620
Histiocytic sarcomaII1NCT03155620
Juvenile xanthogranulomaII1NCT03155620
Langerhans-cell histiocytosisII1NCT03155620
MedulloblastomaII1NCT03155620
NeuroblastomaII1NCT03155620
Non-Hodgkin lymphomaII1NCT03155620
OsteosarcomaII1NCT03155620
Peripheral primitive neuroectodermal tumorII1NCT03155620
Rhabdoid tumorII1NCT03155620
RhabdomyosarcomaII1NCT03155620
SarcomaII1NCT03155620
Wilms TumorII1NCT03155620
Breast neoplasmI1NCT02057133

Everything on Samotolisib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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