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Drugs in development · updated 30 October 2026

Non-Hodgkin lymphoma: drugs in development

Rare diseasePrevalence 1-5 / 10 000 according to Orphanet · ORPHA:547

As of 30 October 2026 there are 258 active clinical trials (recruiting or ongoing, phases I–III) on 269 drugs for non-Hodgkin lymphoma. 133 are experimental, that is not yet approved in the United States.

258Active trials
133Experimental drugs
2Experimental, in phase III

Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.

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Experimental drugs

Not yet approved by the US FDA for any indication.

DrugMost advanced phaseActive trialsReference trial
MecapegfilgrastimPEG-rhG-CSF, PEG-rhG-GSFIII1NCT06520163
OdronextamabOrdspono®III1NCT06230224
CD19I–II6NCT05442515
GolcadomideCC-99282I–II4NCT06090539
GNC-038I–II3NCT05623982
LinperlisibII2NCT07195799
LisaftoclaxAPG-2575, LisafotoclaxII2NCT04496349
NemtabrutinibI–II2NCT03162536
ParsaclisibParsaclisib Incyte Biosciences Distribution B.V.®I–II2NCT04661007
RimiducidAP1903I–II2NCT03301168
SCTB35I–II2NCT07819188
TacabrutidegI–II2NCT05294731
TipifarnibII2NCT04284774
UlixertinibII2NCT03698994
89Zr-Df-IAB22M2CI–II1NCT03533283
AbexinostatPCI 24781I–II1NCT04024696
ALETA-001I–II1NCT06045910
APG-115II1NCT04496349
AZD3470I–II1NCT06137144
AZD4512I–II1NCT07123454
BEX101I–II1NCT07882641
BMS-986458I–II1NCT06090539
CART19I–II1NCT06101381
CART30I–II1NCT02259556
CD19-targetedII1NCT04718883
ChidamideTucidinostat, HBI-8000II1NCT06158386
CHO-H01I–II1NCT05950165
CLIC-1901I–II1NCT03765177
CTX112I–II1NCT05643742
CUCART19II1NCT06462248
EB103I–II1NCT06343311
Elraglusib Oral Tablets9-ING-41II1NCT03678883
EmavusertibCA-4948I–II1NCT03328078
Englumafusp alfaI–II1NCT04077723
GNC-035I–II1NCT06066203
GSK5926371I–II1NCT07607925
HomoharringtonineOmacetaxineI–II1NCT07159906
ICP-490I–II1NCT06845241
IDP-023I–II1NCT06119685
InobrodibCCS1477I–II1NCT04068597

Sorted by most advanced phase and number of active trials. Showing 40 of 133 drugs.

Approved drugs in new trials

Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.

DrugMost advanced phaseActive trialsReference trial
CyclophosphamideCyclophosphamid, CytoxanIII49NCT04529772
FludarabineFludara, FLUDARABINII–III37NCT06756152
RituximabRuxience, RituxanIII34NCT04529772
ObinutuzumabGazyva®, Gazyvaro®III13NCT06191744
EpcoritamabEpkinly®, Tepkinly®III12NCT05578976
IbrutinibPCI 32765, Imbruvica®III11NCT04662255
LenalidomideRevlimid, lenalinomideIII11NCT06191744
AcalabrutinibACP-196, Calquence®III10NCT04529772
EtoposideAvopef®, Etopophos Preservative Free®II–III10NCT06756152
DoxorubicinAdriamycin, DoxorubincinIII9NCT04529772
PirtobrutinibJaypirca®III9NCT05023980
PrednisonePredinisone, CortancylIII8NCT04529772
DexamethasoneDexametasone, DextenzaIII7NCT06230224
VenetoclaxVentoclax, Venclexta®III7NCT03844048
VincristineVincristin, Oncovin [vincristine]III7NCT04529772

Sorted by most advanced phase and number of active trials. Showing 15 of 136 drugs.

All 269 drugs, with the details

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Specific forms

Broader categories

Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D008228 “Lymphoma, Non-Hodgkin”. Prevalence: Orphanet.

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