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Drugs in development · updated 30 October 2026

Acalabrutinib: clinical trials and development status

Other names and codes: ACP-196, Calquence

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 5 November 2020

As of 30 October 2026 Acalabrutinib is in 90 active clinical trials (recruiting or ongoing, phases I–III) for 21 diseases. The most advanced phase is III.

90Active trials
IIIMost advanced phase
21Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Acalabrutinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Chronic lymphocytic leukemiaIII40NCT02970318
Mantle cell lymphomaIII24NCT02972840
Diffuse large B-cell lymphomaIII13NCT04529772
Non-Hodgkin lymphomaIII10NCT04529772
LymphomaIII8NCT04529772
B-cell lymphomaIII5NCT04529772
B-cell leukemiaIII3NCT03836261
LeukemiaIII3NCT03836261
Hematologic neoplasmIII2NCT07635511
Lymphoproliferative disordersIII2NCT04529772
Hematologic DiseasesIII1NCT04662255
Lymphatic system diseaseIII1NCT04529772
NeoplasmIII1NCT04529772
Follicular lymphomaII3NCT04883437
Lymphoma, B-Cell, Marginal ZoneII3NCT04646395
Waldenstrom MacroglobulinemiaII3NCT02180724
Autoimmune hemolytic anemiaII1NCT04657094
GlioblastomaI–II1NCT02586857
Prolymphocytic leukemiaI–II1NCT02029443
Residual neoplasmII1NCT03863184
Burkitt lymphomaI1NCT03666000

Everything on Acalabrutinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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