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Drugs in development · updated 30 October 2026

Ibrutinib: clinical trials and development status

Other names and codes: PCI 32765, Imbruvica

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 21 October 2014

As of 30 October 2026 Ibrutinib is in 92 active clinical trials (recruiting or ongoing, phases I–III) for 37 diseases. The most advanced phase is III.

92Active trials
IIIMost advanced phase
37Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Ibrutinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 37 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Chronic lymphocytic leukemiaIII39NCT03701282
Mantle cell lymphomaIII17NCT01804686
Non-Hodgkin lymphomaIII11NCT04662255
Diffuse large B-cell lymphomaIII10NCT01804686
LymphomaIII8NCT04662255
Waldenstrom MacroglobulinemiaIII7NCT01804686
Follicular lymphomaIII6NCT01804686
B-cell leukemiaIII4NCT05254743
Lymphoma, B-Cell, Marginal ZoneIII4NCT04212013
B-cell lymphomaIII3NCT04662255
Hematologic DiseasesIII2NCT04662255
Lymphoid leukemiaIII2NCT05254743
AnemiaIII1NCT02048813
Bronchiolitis obliterans syndromeIII1NCT01804686
LeukemiaII5NCT06520098
NeoplasmII5NCT05283720
Burkitt lymphomaI–II3NCT03223610
Hairy cell leukemiaII2NCT01841723
Prolymphocytic leukemiaII2NCT02007044
Autoimmune hemolytic anemiaII1NCT05694312
Breast neoplasmI–II1NCT03379428
Central nervous system neoplasmI–II1NCT04446962
Hematologic neoplasmI–II1NCT03328078
Immune System DiseasesI–II1NCT03328078
Immunoproliferative disorderI–II1NCT03328078
Lymphatic system diseaseI–II1NCT03328078
Lymphoproliferative disordersI–II1NCT03328078
Myeloproliferative disordersII1NCT04509700
Neurologic ManifestationsI–II1NCT04446962
Precursor lymphoblastic lymphoma/leukemiaI–II1NCT03960840

Everything on Ibrutinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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