Phuturdex › Diseases › Brain Injuries
Drugs in development · updated 30 October 2026
Brain Injuries: drugs in development
As of 30 October 2026 there are 9 active clinical trials (recruiting or ongoing, phases I–III) on 11 drugs for brain Injuries. 2 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Gamma- GlutamylcysteineGamma- Glutamylcusteine | I | 1 | NCT07050173 |
| Hydrogen | I | 1 | NCT07411911 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AllopurinolAloprim®, Lopurin® | III | 1 | NCT04217421 |
| BiperidenAkineton® | III | 1 | NCT04945213 |
| MannitolD-Mannitol, Bronchitol® | III | 1 | NCT04217421 |
| Tranexamic AcidTransexamic acid, Lysteda® | III | 1 | NCT04387305 |
| Xenon | II | 1 | NCT04696523 |
| Clemastine FumarateTavist-1®, Tavist® | I | 1 | NCT07688746 |
| MetforminRiomet Er®, Glumetza® | I | 1 | NCT06429007 |
| MethadoneMethadose®, Westadone® | Early I | 1 | NCT06810336 |
| RemifentanilUltiva | Early I | 1 | NCT06810336 |
Sorted by most advanced phase and number of active trials.
All 11 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Traumatic brain injury 29 drugs
- Concussion 10 drugs
- Post-traumatic stress disorder 39 drugs
- Depression 73 drugs
- Out-of-hospital cardiac arrest 6 drugs
- Inflammation 85 drugs
- Delirium 14 drugs
- Major depressive disorder 72 drugs
- Psychomotor agitation 10 drugs
- Dwarfism, Pituitary 6 drugs
- Neuroinflammatory diseases 15 drugs
- Spasticity 10 drugs
Broader categories
- Brain Diseases 23 drugs
- Central nervous system disease 38 drugs
- Nervous System Diseases 39 drugs
- Central nervous system trauma 4 drugs
- Wounds and Injuries 25 drugs
- Cerebrovascular disease 8 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: NLM MeSH; NLM MeSH term: D001930 “Brain Injuries”.