Phuturdex › Diseases › Congenital heart disease
Drugs in development · updated 30 October 2026
Congenital heart disease: drugs in development
As of 30 October 2026 there are 6 active clinical trials (recruiting or ongoing, phases I–III) on 8 drugs for congenital heart disease. 0 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AllopurinolAloprim®, Lopurin® | III | 1 | NCT04217421 |
| EmpagliflozinJardiance | III | 1 | NCT06955260 |
| MannitolD-Mannitol, Bronchitol® | III | 1 | NCT04217421 |
| Nitric OxideGenosyl®, Inomax® | III | 1 | NCT04216927 |
| Sacubitril∙ValsartanEntresto Pill, Neparvis® | III | 1 | NCT06693674 |
| BivalirudinAngiomax Rtu®, Bivalirudin In 0.9% Sodium Chloride® | II | 1 | NCT06080074 |
| HeparinUnfractionated heparin, Heparin Sodium Preservative Free® | II | 1 | NCT06080074 |
| SotaterceptACE-011, Winrevair® | II | 1 | NCT07498803 |
Sorted by most advanced phase and number of active trials.
All 8 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Noonan syndrome 4 drugs
- Turner syndrome 6 drugs
- Arrhythmogenic right ventricular cardiomyopathy 5 drugs
- Patent foramen ovale 6 drugs
- Cardiomyopathies 23 drugs
- Heart failure 104 drugs
- Sudden cardiac death 3 drugs
- Migraine 28 drugs
- Patent ductus arteriosus 3 drugs
- Dwarfism 3 drugs
- Ischemic stroke 94 drugs
- Heart Arrest 13 drugs
Broader categories
- Cardiovascular disease 71 drugs
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities 4 drugs
- Heart disease 17 drugs
- Congenital Abnormalities 14 drugs
- Vascular disease 16 drugs
- Wounds and Injuries 25 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D006330 “Heart Defects, Congenital”.