Phuturdex › Diseases › Heart failure
Drugs in development · updated 30 October 2026
Heart failure: drugs in development
As of 30 October 2026 there are 113 active clinical trials (recruiting or ongoing, phases I–III) on 104 drugs for heart failure. 41 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 41 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| EmpagliflozinJardiance | III | 11 | NCT06424288 |
| DapagliflozinForxiga, Dapagliflozin Propanediol | II–III | 10 | NCT07469722 |
| FinerenoneBAY94-8862, Kerendia | III | 9 | NCT07192952 |
| ValsartanPrexxartan®, Diovan® | III | 5 | NCT05508035 |
| FurosemideLasix Onyu®, Furoscix® | II–III | 4 | NCT07469722 |
| SotagliflozinInpefa®, Zynquista® | III | 4 | NCT06217302 |
| ColchicineColchicin, Lodoco® | III | 3 | NCT05873881 |
| Sacubitril | III | 3 | NCT05508035 |
| VericiguatVerquvo® | II–III | 3 | NCT05714085 |
| AcetazolamideDiamox® | II–III | 2 | NCT07469722 |
| InclisiranLeqvio® | III | 2 | NCT06597006 |
| SemaglutideWegovy, Rybelsus | III | 2 | NCT07090343 |
| Sodium Zirconium CyclosilicateLokelma® | III | 2 | NCT06578078 |
| ApixabanEliquis, Abanta® | III | 1 | NCT07471139 |
| AspirinVazalore®, Durlaza® | III | 1 | NCT06082063 |
Sorted by most advanced phase and number of active trials. Showing 15 of 63 drugs.
All 104 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Systolic heart failure 7 drugs
- Heart Failure, Diastolic 4 drugs
- Obesity 233 drugs
- Overweight 139 drugs
- Weight loss 26 drugs
- Cardio-Renal Syndrome 3 drugs
- Type 2 diabetes 171 drugs
Broader categories
- Heart disease 17 drugs
- Cardiovascular disease 71 drugs
- Vascular disease 16 drugs
- Urologic Diseases 16 drugs
- Female urogenital disease 11 drugs
- Female urogenital diseases and pregnancy complications 3 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D006333 “Heart Failure”.