Phuturdex › Diseases › Fatigue
Drugs in development · updated 30 October 2026
Fatigue: drugs in development
As of 30 October 2026 there are 31 active clinical trials (recruiting or ongoing, phases I–III) on 24 drugs for fatigue. 9 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| HBS-301 | III | 2 | NCT07500090 |
| MelatoninSlenyto®, Circadin® | II–III | 2 | NCT05474846 |
| Ponsegromab | II–III | 2 | NCT06989437 |
| ALKS 2680 | III | 1 | NCT07455383 |
| Chemoradiotherapy | II–III | 1 | NCT06758830 |
| IanalumabVAY736 | III | 1 | NCT07621809 |
| Nuvastatic | III | 1 | NCT07669519 |
| Reboxetine | III | 1 | NCT05880342 |
| RimonabantZimulti®, Acomplia® | I–II | 1 | NCT07843108 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ModafinilProvigil® | II–III | 5 | NCT07582458 |
| MethylphenidateConcerta, Relexxii® | II–III | 3 | NCT05474846 |
| DexamethasoneDexametasone, Dextenza | II–III | 2 | NCT02491632 |
| FluvoxamineLuvox®, Luvox Cr® | III | 1 | NCT07359482 |
| SildenafilViagra, Liqrev® | II–III | 1 | NCT06800092 |
| AbrocitinibCibinqo® | II | 1 | NCT06597396 |
| AripiprazoleAbilify Asimtufii®, Opipza® | II | 1 | NCT07714213 |
| BupropionForfivo Xl®, Aplenzin® | I–II | 1 | NCT06609343 |
| Glycerol PhenylbutyrateRavicti® | II | 1 | NCT06887777 |
| InebilizumabUplizna® | II | 1 | NCT07724834 |
| Sodium BicarbonateSodium Bicarbonate In Plastic Container® | II | 1 | NCT04984226 |
| SolriamfetolSunosi® | II | 1 | NCT06170970 |
| TestosteroneNatesto®, Vogelxo® | II | 1 | NCT04301765 |
| Cromolyn SodiumSodium Cromoglicate, Cromoglycate | Early I | 1 | NCT07757555 |
| GuanfacineIntuniv®, Tenex® | Early I | 1 | NCT07757555 |
Sorted by most advanced phase and number of active trials.
All 24 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Nervous System Diseases 39 drugs
- COVID-19 104 drugs
- Memory disorder 7 drugs
- Mental fatigue 4 drugs
- Headache 12 drugs
Broader categories
- Nervous System Diseases 39 drugs
- Mental disorder 24 drugs
- Lung disease 104 drugs
- Respiratory disease 57 drugs
- Digestive System Diseases 36 drugs
- Gastrointestinal disease 22 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D005221 “Fatigue”.