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Drugs in development · updated 30 October 2026

Modafinil: clinical trials and development status

Other names and codes: Provigil

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 Modafinil is in 12 active clinical trials (recruiting or ongoing, phases I–III) for 28 diseases. The most advanced phase is III.

12Active trials
IIIMost advanced phase
28Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Modafinil and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
FatigueIII5NCT07887412
Psychotic disorderIII2NCT07263022
Ulcerative colitisII–III2NCT07582458
ColitisII–III1NCT07582458
Inflammatory bowel diseasesII–III1NCT07582458
Mental disorderIII1NCT07263022
Mitochondrial diseaseIII1NCT07887412
SchizophreniaIII1NCT07263022
StrokeIII1NCT06354985
Postural orthostatic tachycardia syndromeI–II2NCT00262470
TachycardiaI–II2NCT00262470
Chronic painI–II1NCT05351541
Cognitive dysfunctionI–II1NCT05333250
Crohn's diseaseII1NCT07295834
DepressionII1NCT07895134
Major depressive disorderII1NCT07895134
NeoplasmI–II1NCT05333250
Sinus tachycardiaI–II1NCT00262470
Autonomic nervous system diseaseEarly I1NCT01988883
Cardiovascular diseaseEarly I1NCT01988883
Cerebral palsyEarly I1NCT05675098
Nervous System DiseasesEarly I1NCT01988883
Neurobehavioral manifestationEarly I1NCT01988883
Neurodevelopmental disorderEarly I1NCT05675098
Neurologic ManifestationsEarly I1NCT01988883
Orthostatic intoleranceEarly I1NCT01988883
Primary DysautonomiasEarly I1NCT01988883
SpasticityEarly I1NCT05675098

Everything on Modafinil

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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