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Drugs in development · updated 30 October 2026

Guanfacine: clinical trials and development status

Other names and codes: Intuniv, Tenex, Paxneury

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 17 September 2015

As of 30 October 2026 Guanfacine is in 5 active clinical trials (recruiting or ongoing, phases I–III) for 11 diseases. The most advanced phase is II.

5Active trials
IIMost advanced phase
11Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Guanfacine and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Alcohol DrinkingII1NCT03764098
AlcoholismII1NCT06629259
DepressionII1NCT06408246
Neurobehavioral manifestationII1NCT06408246
Autonomic nervous system diseaseEarly I1NCT07757555
Cognitive dysfunctionEarly I1NCT07757555
FatigueEarly I1NCT07757555
Mental fatigueEarly I1NCT07757555
Orthostatic intoleranceEarly I1NCT07757555
Postural orthostatic tachycardia syndromeEarly I1NCT07757555
Primary DysautonomiasEarly I1NCT07757555

Everything on Guanfacine

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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