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Drugs in development · updated 30 October 2026

Loncastuximab Tesirine: clinical trials and development status

Other names and codes: ADCT-402, Zynlonta

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 20 December 2022

As of 30 October 2026 Loncastuximab Tesirine is in 20 active clinical trials (recruiting or ongoing, phases I–III) for 10 diseases. The most advanced phase is III.

20Active trials
IIIMost advanced phase
10Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Loncastuximab Tesirine and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Diffuse large B-cell lymphomaIII5NCT04384484
B-cell lymphomaII–III3NCT05991388
LymphomaIII3NCT04384484
Follicular lymphomaII2NCT07197307
Lymphoma, B-Cell, Marginal ZoneII1NCT05296070
Mantle cell lymphomaII1NCT05249959
Waldenstrom MacroglobulinemiaII1NCT05190705
Non-Hodgkin lymphomaI2NCT07308132
Burkitt lymphomaI1NCT05270057
Chronic lymphocytic leukemiaI1NCT05971251

Everything on Loncastuximab Tesirine

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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