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Drugs in development · updated 30 October 2026

ONC206: clinical trials and development status

NLM verified identityNot approved in the USNo EMA authorisation

As of 30 October 2026 ONC206 is in 3 active clinical trials (recruiting or ongoing, phases I–III) for 16 diseases. The most advanced phase is II.

3Active trials
IIMost advanced phase
16Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow ONC206 and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
ParagangliomaII1NCT07282587
Central nervous system neoplasmI2NCT04541082
EpendymomaI2NCT04541082
GlioblastomaI2NCT04541082
AstrocytomaI1NCT04541082
Choroid plexus neoplasmI1NCT04541082
GliomaI1NCT04541082
GliosarcomaI1NCT04541082
MedulloblastomaI1NCT04541082
MeningiomaI1NCT04541082
Neuroectodermal tumorI1NCT04541082
Neuroepithelial neoplasmI1NCT04541082
OligodendrogliomaI1NCT04541082
PinealomaI1NCT04541082
Primitive neuroectodermal tumorI1NCT04541082
Typical Teratoid Rhabdoid TumorI1NCT04541082

Everything on ONC206

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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