Phuturdex › Diseases › Primitive neuroectodermal tumor
Drugs in development · updated 30 October 2026
Primitive neuroectodermal tumor: drugs in development
As of 30 October 2026 there are 15 active clinical trials (recruiting or ongoing, phases I–III) on 31 drugs for primitive neuroectodermal tumor. 6 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ErsodetugRZ358 | III | 1 | NCT06881992 |
| AMXT 1501 Dicaprate | I–II | 1 | NCT06465199 |
| G207 | I | 1 | NCT03911388 |
| Indoximod | I | 1 | NCT05106296 |
| Iopofosine I 131CLR 131 | I | 1 | NCT03478462 |
| ONC206 | I | 1 | NCT04541082 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| VinblastineVinblastin, Velban® | II–III | 1 | NCT02066220 |
| CyclophosphamideCyclophosphamid, Cytoxan | II | 5 | NCT01878617 |
| TemozolomideTemodal, Temodar | II | 3 | NCT06861244 |
| CisplatinCis Platinum, Cisplatine | II | 2 | NCT01878617 |
| VincristineVincristin, Oncovin [vincristine] | II | 2 | NCT01878617 |
| BelzutifanWelireg® | II | 1 | NCT07167329 |
| EflornithineDFMO, Difluoromethylornithine | I–II | 1 | NCT06465199 |
| GemcitabineGemcitabin, Gemzar | II | 1 | NCT01878617 |
| NivolumabOpdivo, ONO-4538 | II | 1 | NCT06638931 |
| PemetrexedAxtle®, Pemfexy® | II | 1 | NCT01878617 |
| VismodegibErivedge® | II | 1 | NCT01878617 |
| EtoposideAvopef®, Etopophos Preservative Free® | I | 2 | NCT05106296 |
| FludarabineFludara, FLUDARABIN | I | 2 | NCT07087002 |
| IbrutinibPCI 32765, Imbruvica® | I | 1 | NCT05106296 |
| Zoledronic AcidZoledronate, Zoledronic acide | I | 1 | NCT02508038 |
Sorted by most advanced phase and number of active trials. Showing 15 of 25 drugs.
All 31 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Neuroblastoma 95 drugs
- Medulloblastoma 77 drugs
- Osteosarcoma 101 drugs
- Rhabdomyosarcoma 68 drugs
- Ewing sarcoma 82 drugs
- Ependymoma 56 drugs
- Glioma 184 drugs
- Wilms Tumor 37 drugs
- Sarcoma 204 drugs
- Hepatoblastoma 41 drugs
- Rhabdoid tumor 52 drugs
- Peripheral primitive neuroectodermal tumor 17 drugs
Broader categories
- Glandular and epithelial neoplasm 12 drugs
- Germ cell and embryonal neoplasms 35 drugs
- Nerve tissue neoplasm 4 drugs
- Neoplasm 671 drugs
- Neuroectodermal tumor 3 drugs
- Neuroepithelial neoplasm 4 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D018242 “Neuroectodermal Tumors, Primitive”.