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Drugs in development · updated 30 October 2026

Eflornithine: clinical trials and development status

Other names and codes: DFMO, Difluoromethylornithine, Iwilfin, Vaniqa, Ornidyl, Ifinwil

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 19 March 2001

As of 30 October 2026 Eflornithine is in 15 active clinical trials (recruiting or ongoing, phases I–III) for 16 diseases. The most advanced phase is III.

15Active trials
IIIMost advanced phase
16Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Eflornithine and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Colorectal neoplasmIII1NCT01349881
NeuroblastomaII5NCT02559778
AstrocytomaI–II2NCT07468136
Ewing sarcomaII2NCT07321912
GlioblastomaI–II2NCT07468136
GliomaI–II2NCT07468136
OsteosarcomaII2NCT07321912
Breast neoplasmI–II1NCT07287917
Diffuse Intrinsic Pontine GliomaI–II1NCT06465199
MedulloblastomaII1NCT04696029
MelanomaI–II1NCT07287917
OligodendrogliomaI–II1NCT07468136
Primitive neuroectodermal tumorI–II1NCT06465199
Prostatic NeoplasmsII1NCT06059118
Rhabdoid tumorI–II1NCT06465199
Type-1 diabetesII1NCT05594563

Everything on Eflornithine

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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