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Drugs in development · updated 30 October 2026

Siltuximab: clinical trials and development status

Other names and codes: Sylvant

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 22 May 2014

As of 30 October 2026 Siltuximab is in 10 active clinical trials (recruiting or ongoing, phases I–III) for 14 diseases. The most advanced phase is II–III.

10Active trials
II–IIIMost advanced phase
14Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Siltuximab and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Burkitt lymphomaII–III1NCT07570173
Cytokine release syndromeII2NCT07106671
Multiple myelomaII2NCT06679829
B-cell leukemiaII1NCT07709000
Chronic lymphocytic leukemiaII1NCT07709000
Chronic painII1NCT05684692
Hematologic neoplasmII1NCT07709000
Immunoglobulin Light-chain AmyloidosisII1NCT03315026
NeurilemmomaII1NCT05684692
PainII1NCT05684692
SchwannomatosisII1NCT05684692
Endometrial neoplasmI1NCT07870278
Non-Hodgkin lymphomaI1NCT06447376
Ovarian neoplasmI1NCT07870278

Everything on Siltuximab

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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