Phuturdex › Diseases › Amyloidosis
Drugs in development · updated 30 October 2026
Amyloidosis: drugs in development
As of 30 October 2026 there are 28 active clinical trials (recruiting or ongoing, phases I–III) on 24 drugs for amyloidosis. 13 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| ALXN2220 | III | 2 | NCT06183931 |
| EtentamigABBV-383, TNB-383B | III | 2 | NCT07793422 |
| Nucresiran | III | 2 | NCT07052903 |
| [68Ga]CBP8 | III | 1 | NCT05619302 |
| NTLA-2001 | III | 1 | NCT06128629 |
| NXC-201 | III | 1 | NCT07709715 |
| SCTC21C | III | 1 | NCT07388602 |
| AZD0120 | I–II | 1 | NCT07081646 |
| FKC289 | I–II | 1 | NCT07765524 |
| 124I AT-01 | I | 1 | NCT06974877 |
| GC012F | I | 1 | NCT07250269 |
| JNJ-79635322 | I | 1 | NCT05652335 |
| Technetiumtechnetium-99m | I | 1 | NCT05951816 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| DexamethasoneDexametasone, Dextenza | III | 7 | NCT07901725 |
| BortezomibVelcade, Bortezomib Hospira® | III | 5 | NCT07901725 |
| CyclophosphamideCyclophosphamid, Cytoxan | III | 5 | NCT07901725 |
| DaratumumabDarzalex | III | 4 | NCT07901725 |
| VutrisiranAmvuttra® | III | 3 | NCT06679946 |
| AcoramidisAttruby®, Beyonttra® | III | 2 | NCT07116473 |
| EplontersenWainua (Autoinjector)®, Wainua® | III | 1 | NCT05667493 |
| LinvoseltamabLynozyfic® | III | 1 | NCT07901725 |
| Belantamab mafodotinGSK2857916, Blenrep® | I–II | 2 | NCT05145816 |
| VenetoclaxVentoclax, Venclexta® | II | 2 | NCT06629818 |
| PegfilgrastimArmlupeg®, Stimufend® | I | 1 | NCT02909036 |
Sorted by most advanced phase and number of active trials.
All 24 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Immunoglobulin Light-chain Amyloidosis 27 drugs
- Cerebral amyloid angiopathy 4 drugs
- Multiple myeloma 272 drugs
- Familial amyloid neuropathy 4 drugs
- Paraproteinemia 13 drugs
- Cerebral hemorrhage 23 drugs
- Proteostasis Deficiencies 7 drugs
- Smoldering Multiple Myeloma 24 drugs
- Plasma cell neoplasm 45 drugs
- Intracranial Hemorrhages 5 drugs
- Dementia 54 drugs
Broader categories
- Metabolic disease 30 drugs
- Nutritional and metabolic diseases 5 drugs
- Proteostasis Deficiencies 7 drugs
- Immune System Diseases 54 drugs
- Neoplasm 671 drugs
- Lymphoproliferative disorders 51 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D000686 “Amyloidosis”. Prevalence: Orphanet.