Phuturdex › Diseases › Smoking
Drugs in development · updated 30 October 2026
Smoking: drugs in development
As of 30 October 2026 there are 12 active clinical trials (recruiting or ongoing, phases I–III) on 12 drugs for smoking. 5 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AXS-05 | III | 1 | NCT07766655 |
| CytisiniclineCytisine | III | 1 | NCT05102123 |
| Brenipatide | II | 1 | NCT07223840 |
| Fisetin | II | 1 | NCT07676435 |
| PsilocybinPsilocybine | II | 1 | NCT05452772 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| BupropionForfivo Xl®, Aplenzin® | III | 1 | NCT07766655 |
| NicotineNicotrol®, Nicoderm Cq® | II | 3 | NCT07754578 |
| SemaglutideWegovy, Rybelsus | II | 2 | NCT06173778 |
| NiacinNicotinic acid, Niaspan Titration Starter Pack® | II | 1 | NCT05452772 |
| TirzepatideZepbound, Mounjaro | II | 1 | NCT07602699 |
| AlcoholEthanol, Dehydrated alcohol | I | 1 | NCT03294460 |
| CannabidiolEpidiolex, Epidyolex® | I | 1 | NCT05445804 |
Sorted by most advanced phase and number of active trials.
All 12 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Tobacco use disorder 9 drugs
- Vaping 4 drugs
- Cigarette smoking 7 drugs
- Smoking cessation 14 drugs
- Tobacco smoking 4 drugs
- Marijuana Abuse 22 drugs
- Tobacco use 4 drugs
- Acquired Immunodeficiency Syndrome 61 drugs
- Head and neck neoplasms 184 drugs
- Precancerous Conditions 12 drugs
- Inflammation 85 drugs
- Vascular disease 16 drugs
Broader categories
- Mental disorder 24 drugs
- Tobacco use 4 drugs
- Tobacco smoking 4 drugs
- Substance-related disorder 14 drugs
- Respiratory tract neoplasm 21 drugs
- Thoracic Neoplasms 25 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D012907 “Smoking”.