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Drugs in development · updated 30 October 2026

All-trans retinoic acid: clinical trials and development status

Other names and codes: ATRA, Tretinoin, Retinoic Acid, Vesanoid, Altreno, Atralin

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 All-trans retinoic acid is in 34 active clinical trials (recruiting or ongoing, phases I–III) for 39 diseases. The most advanced phase is III.

34Active trials
IIIMost advanced phase
39Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow All-trans retinoic acid and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 39 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Acute promyelocytic leukemiaIII4NCT07504458
AcneII–III2NCT06787222
Autoimmune thrombocytopenic purpuraIII2NCT07597395
LeukemiaIII2NCT07504458
Head and neck neoplasmsIII1NCT06706401
Hematologic DiseasesIII1NCT07504458
Hematologic neoplasmIII1NCT07504458
Hemophagocytic lymphohistiocytosisII–III1NCT07626398
Hypopharyngeal NeoplasmsIII1NCT06706401
Laryngeal neoplasmIII1NCT06706401
NeoplasmIII1NCT07504458
Oropharyngeal NeoplasmsIII1NCT06706401
B-cell lymphomaII2NCT06484920
Colorectal neoplasmII2NCT05999812
MetastasisII2NCT06358677
Multiple myelomaII2NCT06158412
Pancreatic neoplasmII2NCT07586813
ThrombocytopeniaII2NCT07586813
AstrocytomaII1NCT05345002
Autism spectrum disorderII1NCT07079696
Breast neoplasmII1NCT07586826
Digestive system neoplasmII1NCT07586813
Endometrial neoplasmII1NCT07586826
Esophageal squamous cell carcinomaII1NCT06703047
Fallopian tube neoplasmII1NCT07586826
Gastrointestinal neoplasmII1NCT07586813
GliomaII1NCT05345002
Hodgkin lymphomaII1NCT06484920
LeiomyosarcomaII1NCT06528769
Lung neoplasmII1NCT07586826

Everything on All-trans retinoic acid

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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