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Drugs in development · updated 30 October 2026

Avutometinib: clinical trials and development status

Other names and codes: VS-6766, RO5126766

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 Avutometinib is in 24 active clinical trials (recruiting or ongoing, phases I–III) for 20 diseases. The most advanced phase is III.

24Active trials
IIIMost advanced phase
20Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Avutometinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Pancreatic neoplasmII4NCT07126158
GlioblastomaI–II3NCT06630260
Ovarian neoplasmII3NCT07747506
Brain NeoplasmsI–II2NCT06194929
MetastasisII2NCT07743554
Adenocarcinoma of the lungII1NCT06495125
Breast neoplasmI–II1NCT05608252
Lung neoplasmII1NCT06495125
MelanomaI–II1NCT06194929
Neurofibromatosis 1II1NCT07743554
NeurofibrosarcomaII1NCT07743554
Non-small-cell lung carcinomaI–II1NCT05074810
Stomach neoplasmII1NCT06487221
Thyroid neoplasmII1NCT06007924
Uterine cervix neoplasmII1NCT05512208
Carcinoma, EndometrioidI1NCT03875820
Central nervous system neoplasmI1NCT06104488
NeoplasmI1NCT06104488
NeuroblastomaI1NCT06104488
Plexiform neurofibromaI1NCT06104488

Everything on Avutometinib

In Phuturdex you get every trial with sponsors, countries and dates, development events, FDA and EMA approvals, patents and exclusivities, orphan designations and safety alerts, with PDF and Excel export. Free until 31 March 2027.

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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