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Drugs in development · updated 30 October 2026

Diphenhydramine: clinical trials and development status

Other names and codes: Benadryl, Benadryl Preservative Free, Benylin

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 Diphenhydramine is in 30 active clinical trials (recruiting or ongoing, phases I–III) for 30 diseases. The most advanced phase is III.

30Active trials
IIIMost advanced phase
30Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Diphenhydramine and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Multiple myelomaIII4NCT04270409
Lupus nephritisIII2NCT04221477
Burkitt lymphomaII–III1NCT07570173
DystociaII–III1NCT06702670
Multiple sclerosisIII1NCT07472413
Non-small-cell lung carcinomaIII1NCT06704620
Systemic lupus erythematosusIII1NCT04963296
Chronic lymphocytic leukemiaII2NCT07709000
Hairy cell leukemiaII2NCT01059786
Acute liver failureII1NCT04862221
Autism spectrum disorderII1NCT05501678
Autistic DisorderII1NCT05501678
B-cell leukemiaII1NCT07709000
CarcinomaII1NCT05977998
Crohn's diseaseI–II1NCT04224558
Follicular lymphomaII1NCT06043323
Hematologic neoplasmII1NCT07709000
Hepatic encephalopathyII1NCT04862221
Hepatic insufficiencyII1NCT04862221
Liver diseaseII1NCT04862221
Liver failureII1NCT04862221
Mucinous adenocarcinomaI–II1NCT06207305
Residual neoplasmII1NCT01059786
Alcohol DrinkingI1NCT06070649
Alcohol-related disordersI1NCT06070649
AlcoholismI1NCT06070649
Endometrial neoplasmI1NCT07870278
Non-Hodgkin lymphomaI1NCT00840853
Ovarian neoplasmI1NCT07870278
Precursor lymphoblastic lymphoma/leukemiaI1NCT00840853

Everything on Diphenhydramine

In Phuturdex you get every trial with sponsors, countries and dates, development events, FDA and EMA approvals, patents and exclusivities, orphan designations and safety alerts, with PDF and Excel export. Free until 31 March 2027.

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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