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Drugs in development · updated 30 October 2026

Mirdametinib: clinical trials and development status

Other names and codes: Gomekli, Ezmekly

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 17 July 2025

As of 30 October 2026 Mirdametinib is in 17 active clinical trials (recruiting or ongoing, phases I–III) for 31 diseases. The most advanced phase is II.

17Active trials
IIMost advanced phase
31Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Mirdametinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 31 diseases.

DiseaseMost advanced phaseActive trialsReference trial
AstrocytomaII2NCT07891286
GliomaII2NCT07521657
MelanomaII2NCT07891286
NeurofibromatosesII2NCT03962543
Neurofibromatosis 1II2NCT03962543
Arachnoid cystII1NCT07891286
Arteriovenous malformationII1NCT05983159
Central nervous system neoplasmI–II1NCT07539441
Chronic lymphocytic leukemiaII1NCT07061951
Cystic lymphangiomaII1NCT05983159
EpendymomaII1NCT07891286
GangliogliomaI–II1NCT04923126
GanglioneuromaI–II1NCT04923126
GlioblastomaII1NCT07521657
Histiocytosis, SinusII1NCT06153173
Juvenile xanthogranulomaII1NCT06153173
Langerhans-cell histiocytosisII1NCT06153173
LiposarcomaI–II1NCT06843967
LymphangiomaII1NCT05983159
Lymphatic AbnormalitiesII1NCT05983159
MetastasisI–II1NCT05937906
Myxoid liposarcomaI–II1NCT06843967
Neurocutaneous melanosisII1NCT07891286
NeurocytomaI–II1NCT04923126
Neuroepithelial neoplasmI–II1NCT04923126
NeurofibromaII1NCT03962543
Non-small-cell lung carcinomaI–II1NCT05937906
OligodendrogliomaI–II1NCT04923126
Plexiform neurofibromaII1NCT03962543
Vascular malformationII1NCT05983159

Everything on Mirdametinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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