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Drugs in development · updated 30 October 2026

Selpercatinib: clinical trials and development status

Other names and codes: LOXO-292, Retevmo

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 11 February 2021

As of 30 October 2026 Selpercatinib is in 15 active clinical trials (recruiting or ongoing, phases I–III) for 39 diseases. The most advanced phase is III.

15Active trials
IIIMost advanced phase
39Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Selpercatinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 39 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Non-small-cell lung carcinomaIII7NCT04194944
Medullary carcinomaIII5NCT04211337
Thyroid neoplasmII6NCT04280081
NeoplasmII4NCT06458036
Papillary thyroid cancerII4NCT04759911
Central nervous system neoplasmII3NCT03155620
Lung neoplasmII3NCT04268550
SarcomaII3NCT04320888
Breast neoplasmI–II2NCT03157128
Bronchial neoplasmI–II2NCT03157128
Carcinoma, BronchogenicI–II2NCT03157128
Colonic neoplasmI–II2NCT03157128
Endocrine gland neoplasmI–II2NCT03157128
Endocrine system diseaseI–II2NCT03157128
EpendymomaII2NCT04320888
Ewing sarcomaII2NCT04320888
GliomaII2NCT04320888
Head and neck neoplasmsI–II2NCT03157128
HepatoblastomaII2NCT04320888
Langerhans-cell histiocytosisII2NCT04320888
Lung diseaseI–II2NCT03157128
MedulloblastomaII2NCT04320888
NeuroblastomaII2NCT04320888
Non-Hodgkin lymphomaII2NCT04320888
OsteosarcomaII2NCT04320888
Peripheral primitive neuroectodermal tumorII2NCT04320888
Respiratory diseaseI–II2NCT03157128
Respiratory tract neoplasmI–II2NCT03157128
Rhabdoid tumorII2NCT04320888
RhabdomyosarcomaII2NCT04320888

Everything on Selpercatinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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