Phuturdex › Diseases › Aortic valve stenosis
Drugs in development · updated 30 October 2026
Aortic valve stenosis: drugs in development
As of 30 October 2026 there are 12 active clinical trials (recruiting or ongoing, phases I–III) on 13 drugs for aortic valve stenosis. 2 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Ataciguat | II–III | 1 | NCT07001800 |
| Pelacarsen | II | 1 | NCT05646381 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| InclisiranLeqvio® | III | 2 | NCT06597006 |
| ColchicineColchicin, Lodoco® | III | 1 | NCT05162742 |
| Protamine sulfate | III | 1 | NCT06215378 |
| SemaglutideWegovy, Rybelsus | III | 1 | NCT07090343 |
| DapagliflozinForxiga, Dapagliflozin Propanediol | II | 1 | NCT07539259 |
| EplerenoneEpleronone, Inspra® | II | 1 | NCT07539259 |
| Folic acidQuiofic®, Folvite® | II | 1 | NCT05861648 |
| Icosapent ethylVascepa®, Vazkepa® | II | 1 | NCT06466278 |
| PioglitazoneActos, Pioglitazone Accord® | II | 1 | NCT05875675 |
| SpironolactoneCarospir®, Aldactone® | II | 1 | NCT07539259 |
| VericiguatVerquvo® | II | 1 | NCT07715279 |
Sorted by most advanced phase and number of active trials.
All 13 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Hypertrophic cardiomyopathy 16 drugs
- Cardiomyopathies 23 drugs
- Left ventricular hypertrophy 4 drugs
- Heart failure 104 drugs
- Friedreich ataxia 9 drugs
- Heart disease 17 drugs
- Neoplasm 671 drugs
- Cardiovascular disease 71 drugs
- Pulmonary fibrosis 34 drugs
- Lysosomal storage disease 11 drugs
Broader categories
- Heart disease 17 drugs
- Heart valve disease 3 drugs
- Aortic valve disease 4 drugs
- Cardiovascular disease 71 drugs
- Metabolic disease 30 drugs
- Nutritional and metabolic diseases 5 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D001024 “Aortic Valve Stenosis”.