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Drugs in development · updated 30 October 2026

Spironolactone: clinical trials and development status

Other names and codes: Carospir, Aldactone, Qaialdo

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 26 May 2023

As of 30 October 2026 Spironolactone is in 21 active clinical trials (recruiting or ongoing, phases I–III) for 23 diseases. The most advanced phase is III.

21Active trials
IIIMost advanced phase
23Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Spironolactone and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Rheumatoid arthritisIII1NCT05092984
Heart failureII3NCT07857772
Arterial hypertensionII2NCT07645300
Chronic renal insufficiencyII2NCT07715318
AcneII1NCT07473895
AnemiaII1NCT07715318
Aortic aneurysmI–II1NCT07483177
Aortic valve stenosisII1NCT07539259
Arrhythmogenic right ventricular cardiomyopathyII1NCT03593317
Arterial pulmonary hypertensionII1NCT01712620
Cardiovascular diseaseII1NCT07304817
Cerebral hemorrhageII1NCT04760717
Chronic kidney failureII1NCT07715318
GlioblastomaI–II1NCT07431216
Hypertension, Pregnancy-InducedII1NCT07041281
Ischemic strokeII1NCT04760717
Pre-eclampsiaII1NCT07041281
Thoracic aortic aneurysmI–II1NCT07483177
Alcohol DrinkingI1NCT05807139
Alcohol-related disordersI1NCT05807139
AlcoholismI1NCT05807139
HyperandrogenismEarly I2NCT04723862
Polycystic Ovary SyndromeEarly I2NCT04723862

Everything on Spironolactone

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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