Phuturdex › Diseases › Chronic renal insufficiency
Drugs in development · updated 30 October 2026
Chronic renal insufficiency: drugs in development
As of 30 October 2026 there are 120 active clinical trials (recruiting or ongoing, phases I–III) on 104 drugs for chronic renal insufficiency. 53 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 53 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| DapagliflozinForxiga, Dapagliflozin Propanediol | III | 12 | NCT05374291 |
| FinerenoneBAY94-8862, Kerendia | III | 4 | NCT05196035 |
| BaxdrostatBaxfendy® | III | 3 | NCT06742723 |
| ColchicineColchicin, Lodoco® | III | 3 | NCT06998862 |
| EmpagliflozinJardiance | III | 3 | NCT06531824 |
| SemaglutideWegovy, Rybelsus | III | 3 | NCT06058585 |
| AtrasentanVanrafia® | III | 2 | NCT07498335 |
| EtelcalcetideParsabiv® | III | 2 | NCT03969329 |
| Folic acidQuiofic®, Folvite® | III | 2 | NCT05284656 |
| Iron sucroseVenofer | III | 2 | NCT03619850 |
| Pentoxifyllinepentoxyifylline, Trental® | III | 2 | NCT05284656 |
| Sodium Zirconium CyclosilicateLokelma® | III | 2 | NCT06578533 |
| CinacalcetSensipar®, Cinacalcet Accordpharma® | III | 1 | NCT07122401 |
| DesmopressinDDAVP, Desmopresin | III | 1 | NCT06337838 |
| FerumoxytolFerabright®, Feraheme® | III | 1 | NCT03619850 |
Sorted by most advanced phase and number of active trials. Showing 15 of 51 drugs.
All 104 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Chronic kidney failure 48 drugs
- Renal Insufficiency 51 drugs
- Cardiovascular disease 71 drugs
- Heart failure 104 drugs
- Kidney disease 38 drugs
- Chronic kidney disease-mineral and bone disorder 4 drugs
- Atherosclerosis 34 drugs
- Diabetes 91 drugs
- Anti-neutrophil cytoplasmic antibody-associated vasculitis 35 drugs
- Multiple myeloma 272 drugs
- Atrial fibrillation 32 drugs
- Atrial flutter 6 drugs
Broader categories
- Female urogenital disease 11 drugs
- Female urogenital diseases and pregnancy complications 3 drugs
- Urogenital Diseases 16 drugs
- Male urogenital disease 19 drugs
- Renal Insufficiency 51 drugs
- Urologic Diseases 16 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D051436 “Renal Insufficiency, Chronic”.